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While the trial found that ipamorelin did not improve measured outcomes (time to first tolerated meal and first bowel movement) better than a placebo [6], the data indicated that it may help patients recover faster following open laparotomy [7]

They are not affirmatively cleared in the same way Category 1 peptides are

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Hypoxia-driven extracellular lactate can also be imported into macrophages via MCT1, increasing macrophage histone lactylation (notably H3K18la) and activating TNFSF9 transcription to reinforce an M2-like, tumor-promoting phenotype

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Frontiers in Bioengineering and Biotechnology, 9