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Estrogen stimulates mast cells to release histamine, and histamine, in turn, stimulates the ovaries to produce more estrogen

All experiments were carried out by an experimenter who was blind to genotype, whenever possible

Box plot elements: Box spans the interquartile range (IQR) (25th75th percentile), central line is the median (50th percentile), + marks the mean, whiskers extend to the lowest and highest values within 1.5 IQR of the box, and values beyond that range are shown individually

Accordingly, there have been a number of non-pharmacological interventions tailored to address the underlying environmental and lifestyle risk factors that have demonstrated promising, though not conclusive, improvements in ASD symptoms