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DOI: 10.1105/tpc.108.059485 96

Cells in the gut produce hormones (enteroendocrine cells) such as glucagon-like peptide (GLP-1), gastric inhibitory peptide (GIP), peptide YY, secretin, gherlin, gastrin, and many others

For patients and healthcare providers, the appeal is clear: retatrutide may finally address the full spectrum of metabolic dysfunctionfrom obesity and diabetes to fatty liver diseaseoffering a treatment option that is both broader in scope and more powerful in effect

With stress and anxiety disorders, this system can stay stuck in overdrive, leading to an increased heart rate and heart rhythm disturbances

Donald Vollmer Body Works Franklin & Nolensville, TN A 2025 review published in PubMed found that while GLP-1 receptor agonists are effective in reducing fat mass, up to 40% of total weight lost can come from fat-free mass