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For instance, in August 2024, Eli Lilly and Company announced positive topline results from the SURMOUNT-1 trial, a three-year study evaluating the effectiveness and safety of tirzepatide (marketed as Zepbound and Mounjaro) administered once weekly for long-term weight management and delaying the progression to diabetes in adults with pre-diabetes and obesity or overweight
Positive findings Positive findings were identified in 21 of 34 patients (62%)
How It Works: When healthy fats reach the lower intestine, they bind to fatty acid receptors on L-cells
Dulaglutide Dulaglutide (Trulicity) is also a GLP-1 agonist, and it has a similar mechanism of action to liraglutide
But here is the critical update that changes this entire conversation
Clinical trials demonstrate that GLP-1 weight loss medications, when combined with lifestyle modifications, can produce 15-20% total body weight loss over 52 weeks
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