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Despite the progress made in understanding the mechanisms of ferroptosis, several significant issues remain regarding its translation into clinical therapy

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In the tumor microenvironment, macrophage phenotypic polarization exhibits significant functional differences, primarily classified into the M1 phenotype, which has tumor-suppressive effects, and the M2 phenotype, which promotes tumor development (74)

Metallothionein-3 (MT3), a brain-specific metalloprotein, serves as a primary antioxidant that rapidly responds to oxidative stress