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Because Wegovy affects digestion, the most common side effects are gastrointestinal, including nausea, diarrhea, constipation, and abdominal pain

10.1523/JNEUROSCI.2179-17.2018 [DOI] [PMC free article] [PubMed] [Google Scholar] Brown MK, Strus E, Naidoo N (2017) Reduced sleep during social isolation leads to cellular stress and induction of the unfolded protein response

These effects were not reproduced in 3-AR knockout mice, suggesting that the 3-AR plays a key role in the compounds chronic metabolic effects (Heffernan et al

The answer remains a matter of debate (32)

Patients combining GLP-1 with other treatments Some patients explore combining GLP-1 medications with other supplements or treatments

While semaglutide should be safe for most people, it often causes gastrointestinal side effects early in treatment, including:8 Bloating Abdominal pain Nausea Vomiting Diarrhea Belching Flatulence While these arent the most pleasant or flattering side effects, they often fade with use as your body adjusts to the effects of the medication