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In Victoza clinical trials, severe gastrointestinal adverse reactions were reported more frequently among patients receiving Victoza (1.2 mg 4.4 %, 1.8 mg 4.2 %) than placebo (1.1 %)

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The primary drug interaction concern with semaglutide involves medications that require rapid absorption for effectiveness or those with narrow therapeutic windows

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However, while Wegovy and Saxenda target just GLP-1 receptors, Zepbound is considered a dual agonist, meaning it targets GLP-1 receptors and the receptors for the hormone GIP