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Common impurities include: -Deamidation (+0.984 Da) -Oxidation (+16 Da) -Des-acylated forms (266 Da) -Truncated peptides -Isomerization (Asp/isoAsp) These must be identified and quantified during impurity profiling

Dong Y, Jiang H (2016) Microbial production of metabolites and associated enzymatic reactions under high pressure

6-month duration may not capture full benefit

Lower diabetes risk: In people with elevated blood sugar, for every 2.2 pounds of weight loss, the risk of developing diabetes drops 16%

The mechanism likely involves correction of oxidative stress and modulation of glutamate signaling via the cystine-glutamate antiporter (system Xc-) [73][74]

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