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Methods Literature search and selection This narrative review was constructed through a comprehensive search of peer-reviewed publications, authoritative texts, and official anti-doping reports related to Meldonium, metabolic modulation, and athletic performance

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[1] [4] Tirzepatide's mechanism of action targets the incretin system through GIP and GLP-1 receptors, which are not directly involved in the hypothalamic-pituitary-adrenal (HPA) axis that regulates cortisol production

Instead, only activation of Oxtr -containing neurons, exclusively intestinal IGLEs that detect stretch, potently suppressed food intake, while various subtypes of mucosal ending neurons, which are classically thought to sense gut peptides, had no effect 28