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Additionally, the trauma-exposed group received a follow-up assessment approximately 8 months after the baseline assessment (20 months since trauma exposure, Supplementary Fig

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In a similar rat model, Mazo et al., 2013 [17] showed that the administration of SNAC at 1.4 mg/kg daily by gavage for 8 weeks could reduce the collagen-occupied area associated with an upregulation of matrix metalloproteinases-13 and -9 and a downregulation of heat-shock protein-60, tissue inhibitors of metalloproteinase-2, TGF-1, and collagen-1