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doi: 10.3390/medicines3040025 226 KannaiyanSKJeyakumariANagalakshmiKVenkateshwarluG

A: Cellular senescence is a state where damaged cells permanently stop dividing but do not die, lingering as zombie cells that secrete inflammatory factors

The importance of acetyl-CoA metabolism in cancer cells is further underscored by studies which show that the rate of synthesis of acetyl-CoA, mediated by the mammalian cytosolic enzyme acetyl-CoA synthetase (ACSS2), is significantly elevated in several malignant cell lines 67,68 in order to satisfy their high energy requirements, particularly under conditions of metabolic stress

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Of course, pharmacotherapy is not the sole solution for weight loss