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Any maternal medication that enters breast milk poses a theoretical risk to the nursing infant, whose metabolic capacity and tolerance thresholds differ significantly from adults

Grapefruit juice increased the mean area under the oxycodone concentration-time curve (AUC(0-)) by 1.7 fold, the peak plasma concentration by 1.5-fold and the half-life of oxycodone by 1.2-fold as compared to water

However, for many, injections remain essential

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Gosk S, Vermehren C, Storm G, Moos T