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Moreover, the authors declare that they have received funding from different probiotic and food supplement companies to perform mechanistic and clinical research related to aspects discussed in this review

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The dose escalation protocol matters ENORMOUSLY here: Rushing the titration is where most people run into trouble with GI distress that could otherwise be prevented with patience and proper medical oversight

In the study above, the authors note that more drugs [from postauricular injection] concentrated in the inner ear for longer therapeutic time, and less systemic delivery implied less risk of side effects. Practical Considerations: Injection Scheduling Protocol typically involves multiple injections over 12 weeks