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By limiting the most probable DPP-8-selectivity imparting modification points in DPP-8/9 inhibitors to areas of space that are topologically similar to the piperazine ring, this strategy may serve as a useful platform for developing future selective DPP-8 inhibitors, including novel chemotypes

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[PMID:19326450] Souzaki R, Kawakubo N, Matsuura T, et al

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