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IL-4 Inhibits the Melanogenesis of Normal Human Melanocytes through the JAK2-STAT6 Signaling Pathway

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Med J Babylon (2016) 13:34753

Laboratory studies demonstrated: Enhanced fatty acid oxidation in treated animal models Increased plasma glycerol release (an established index of active lipolysis) Elevated mitochondrial fatty acid oxidation capacity Both energy expenditure and fat oxidation increases even without classical -AR pathways The peptide appears to modulate metabolic flexibility in adipocytes

45 The vitamin D-folate hypothesis highlights a potential role for folate in preventing DNA damage through driving the evolution of skin pigmentation