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In clinical trials involving semaglutide, the incidence of thyroid cancer in treated patients was less than 1%, and no statistically significant increase compared to placebo was established

Free Radic Biol Med (2012) 52(1):16

An analysis of risk-matched pairs might have been more illuminating than just two pools of patients with potentially nonrandom assignment of medications

At a tolerated treatment stage: nausea may decrease, although persistent symptoms require review

In fact, real world studies indicate these GI adverse events develop in between 40-70% of GLP-1 treated patients

TSH is the "messenger" hormone sent by the brain to tell the thyroid to work harder