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But you can also have a vitamin B12 deficiency without having anemia

doi: 10.1093/jxb/erv063 32 HllerK.KirlyL.KnstlerA.MllerM.GullnerG.FattingerM.et al

Activated IRS-1 recruits and activates phosphoinositide 3-kinase (PI3K), resulting in phosphatidylinositol 3,4,5-trisphosphate (PIP3) generation at the plasma membrane

When blood glucose climbs above approximately 180 mg/dL, the kidneys can no longer reabsorb the excess sugar

- Most evidence comes from animal studies - Human data is extremely limited - No FDA approval for orthopedic use - Clinical benefit in musculoskeletal conditions remains unproven While the biology is interesting, potential does not equal proven clinical outcomes

Hum Gene Ther 2017;28:111821