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With the increasing cost and limited supplies of fish feed protein, HFDs are used currently in aquaculture for their protein sparing effect, which means that the energy that is normally sourced from protein consumption is replaced by lipid-sourced energy 11,12

This mechanism addresses the root biological cause of weight gain rather than relying on willpower alone

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A collection of Curbside Consultation published in AFP is available at Copyright 2026 by the American Academy of Family Physicians

Excessive production of ROS and reactive carbonyls further increases endoplasmic reticulum stress

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