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In the present study, it was hypothesized that uric acid could elevate oxidative stress in rat VSMCs in a dose- and time-dependent manner

Sies H, Cadenas E (1985) Oxidative stress: damage to intact cells and organs

The results showed that during the 16-week treatment period, patients who received the highest dosage (120 mg twice daily) of danuglipron experienced an average reduction in HbA1c of 1.16 percentage points and a weight loss of 4.17 kilograms

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