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Proinflammatory cytokines, aging, and age-related diseases

Tetrahydrobiopterin (BH4) is of central importance for the normal functioning of the central nervous system

For example, chronic alcohol feeding in diethylnitrosamine (DEN)-induced HCC mice leads to reduced antitumor CD8+ T cells and an increase in tumor-associated macrophages (TAMs), which tend to polarize toward the M2 phenotype after alcohol exposure (89)