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As a direct measurement of unbound concentrations of drugs (C u,cell ) inside the brain parenchymal cells cannot be achieved in practice, indirect methods combining the brain slice assay and brain homogenate method have been established to estimate C u,cell (97, 104)

Symptoms of anemia caused by a vitamin deficiency include a sore mouth, diarrhea, and pasty or yellowing skin

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In the acute stress protocol, caffeine was administered in 1 [28] or 2 days [26, 27] with a dose varying from 3 mg.kg -1 ip