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Together, these data suggest that BDHI is a mildly reactive electrophile that can acts as a covalent protein modifier upon interaction within protein binding pockets and its proteomic reactivity and selectivity can be largely modulated by fragments appended to the warhead

Porter C, Constantin-Teodosiu D, Constantin D, Leighton B, Poucher SM, Greenhaff PL

In aged mouse models, researchers observed that FOXO4-DRI administration was associated with changes in senescence biomarker levels and functional parameters