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Ala 18 The mutation of GIP His 18 to Ala reinforced its insulinotropic effect.27 In CY-5 experiments, replacing Arg 18 from GCG with Ala simultaneously improved both the GLP-1 and GIP activity.16 Using the Ala 18 from GLP-1 may support GIP activity by chance

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What makes GLP-1 drugs particularly intriguing is that they appear to work through a mechanism distinct from traditional addiction treatments

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