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Apart from directly stimulating hepatocyte proliferation, KCs also engage with other subsets of non-parenchymal cells, indirectly influencing and enhancing the liver regeneration process through cellcell interactions or paracrine signaling via the production of inflammatory factors
More broadly, it underscores a key principle in neuromodulationwhen brain stimulation changes both symptoms and circuits, it moves from hopeful therapy to mechanistic medicine
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