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Mistakes to avoid: Taking with caffeine (wait 2 hours between coffee and glutathione) Expecting overnight results (skin changes take 2-3 months minimum) Combining with junk food or alcohol (depletes glutathione faster than supplements restore it) Using low-quality products without third-party testing Taking on a completely empty stomach if it causes nausea Poor lifestyle habits undermine supplement benefits

Other potential adverse effects of high dose and long-term glutathione supplementation include: Lightening of hair colour: A logically expected effect since hair colour is dependent on the amount and type of melanin which may be altered by glutathione supplementation