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NF-B-regulated gene products are extensively involved in inflammation and cartilage degradation (COX-2, MMPs) and apoptosis (caspase-3)

Front Endocrinol (Lausanne) 2013;4:64

5 The role of iron in CNS resident cells As the relationship between iron and glial cells were already covered in previous reviews (4648) [see the previous references for a detailed review on the subject], in this section, we briefly mention the role of iron in different CNS resident cell types that are relevant to MS pathophysiology and highlight the contribution of the iron dyshomeotasis in these cells as an underpinning mechanism of disease progression