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The lawsuit was dismissed in 2013

Serious side effects are extremely uncommon, but allergic reactionsincluding rash, swelling, or breathing difficultiesshould be treated as medical emergencies

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Lower calorie intake may alter levels of hormones that influence alertness and rest, which can subtly affect how sleepy you feel at night

Normal thyroid levels are also seen, and occasionally hypothyroidism, which may assist in causing goiter (though it is not the cause of Graves' disease)

However, challenges like poor bioavailability, complex multi-component interactions, and lack of standardization still hinder their widespread use