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3Conclusion The complex interaction between various cytosolic and intranuclear components with NRF-2, although better understood, continues to encounter a lack of information, leading us to clearly identify under which conditions its action is activated or suppressed by means of various, already identified clinical situations

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[DOI] [PMC free article] [PubMed] [Google Scholar] 49.Yang R., Yu H., Wu J., Chen H., Wang M., Wang S., Qin X., Wu T., Wu Y., Hu Y

These preclinical findings further implicate glucagon activation as the distinguishing factor between incretin receptor mono-, dual-, and triagonists, and they point to unimolecular polypharmacology as an efficient way to target several mechanisms causing obesity

[DOI] [PubMed] [Google Scholar] 13

eGFR = estimated GFR