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Weight loss expectations: In landmark trials such as STEP 1 (Semaglutide Treatment Effect in People with obesity) and SCALE (Satiety and Clinical Adiposity Liraglutide Evidence), participants achieved average weight reductions of 14.9% of initial body weight over 68 weeks with semaglutide 2.4 mg weekly, and approximately 8% with liraglutide 3.0 mg daily

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This is especially true when distinguishing nuclear from mitochondrial DNA damage or quantifying basal lesion levels (Gonzalez-Hunt et al., 2018)

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If supplementation is necessary, limiting intake to 3,000 IU daily provides adequate support without approaching dangerous thresholds