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10.1371/journal.pone.0019478 [DOI] [PMC free article] [PubMed] [Google Scholar] 76.Kos K, Baker AR, Jernas M, Harte AL, Clapham JC, OHare JP, et al

MC5R Activation: Can influence sebaceous gland function, though this is a less commonly studied effect

Diagnostic features: Intranuclear inclusions are round, distinct, usually eccentrically located, and may partially or almost completely fill the nucleus

However, the maximal glycaemic effect is usually seen after several months and following dose titration, not immediately upon reaching steady state

This also reduces the chance of digestive discomfort

In such an event, the line of treatment should be by addressing the signs and symptoms first