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5.1 Signaling mechanisms from the gut microbiota to the brain SCFAs, BAs, and other metabolites have been implicated as signaling molecules mediating host-microbe communication via EECs and ECCs by acting on the corresponding receptors, which can regulate many CNS activities, including energy and glucose metabolism as well as HPA activity (400404)

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By contrast, while PCSK1/3 mRNA increases in patients with diabetes compared to healthy individuals, the density of PC1/3-positive cells decreases (Jorsal et al., 2018), suggesting a posttranslational impact on GLP-1 availability

Sulforaphane prevents maleic acid-induced nephropathy by modulating renal hemodynamics, mitochondrial bioenergetics and oxidative stress

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Dysregulation of energy metabolism in alzheimers disease