Three things happen: gastric acid production drops dramatically, intrinsic factor production declines because most parietal cells are in the bypassed stomach, and food no longer passes through the duodenum, where the transfer to this carrier normally occurs
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Paradoxically, it actually increases blood glucose, but at the same time increases the expenditure of energy in cells of the body, raises body temperature, and suppresses appetite. By adding glucagon to the mix, GLP-1 and GIP end up neutralizing its glucose-enhancing effect, leaving the remaining functionalities of all three hormones working together to enhance weight loss
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For patients on oral semaglutide who must take antibiotics, timing becomes critical
Mol Pharmacol 67:280287 [DOI] [PubMed] [Google Scholar] Koch T, Wu DF, Yang LQ, Brandenburg LO, Hllt V