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This trial addressed a common clinical scenario where physicians must choose between adding an injectable incretin mimetic or intensifying with insulin

These studies should incorporate sensitive biomarkers, including neuroimaging (MRI-based volumetry and functional connectivity), cerebrospinal fluid A/tau ratios, and emerging blood-based markers of oxidative stress and inflammation

Acute administration effects suggest alternative metabolic mechanisms involving direct effects on cellular oxidative capacity

Treatment with MOUNJARO 5 mg once weekly and 10 mg once weekly for 30 weeks, both pooled and individually, resulted in a statistically significant reduction in HbA1c compared with placebo (see Table 9)

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