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J Clin Investig 88(1):168173 Semple RK, Savage DB, Cochran EK, Gorden P, ORahilly S (2011) Genetic syndromes of severe insulin resistance

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Side Effects Comparison Common Side Effects for Both Medications Both semaglutide and tirzepatide can cause similar side effects, mainly stomach-related issues: Nausea (most common) Vomiting Diarrhea Constipation Stomach pain Loss of appetite Most side effects are mild to moderate and happen mainly when starting the medication or increasing the dose

Step two: physician consultation

At 2.4 mg, the GLP-1 receptor activation is at its peak