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Interestingly, the female steady-state is low for S near 1 and also low for S = 3.31, but at intermediate values of S , the female steady-state is considerably higher than that the male's

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Metabolism, hormones, insulin resistance, inflammation, and genetics all play major roles

PMID: 12824092, DOI: 10.1001/archinte.163.12.1430

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