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Quick Answer: Tirzepatide typically expires within 1 to 2 years if kept refrigerated and unopened, but once removed from the fridge or punctured, its lifespan drops significantly

The user base is simultaneously growing in absolute terms (new adopters coming in as costs fall and access expands) and cycling at high rates (a majority discontinuing within 12 months)

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In research models, GLP-1 receptor activation is associated with glucose-dependent insulin secretion, suppression of glucagon release, slowed gastric emptying, and reduced food intake through central appetite-regulating circuits