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No serious drug interactions exist, but GLP-1's effect of slowing gastric emptying can intensify existing bile-related diarrhea or bloating

While the ability of GLP-1 and its stable analogues, exendin-4 (EX4) for example, to reduce food intake is well established, the brain mechanisms governing GLP-1 receptor (GLP-1R)-induced anorexia are still poorly understood

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In this study, we identify a brain-to-gut circuitPVN Glu DMV Ach small intestineas essential for opioid-induced constipation