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Mechanism of Action At the molecular level, IGF-1 LR3 is studied for its interaction with insulin-like growth factor-1 receptors (IGF-1R) and related receptor systems

Dinh Tran, MD at Family Healthcare Shoreline for Oral GLP-1 Weight Loss

Higher baseline BMI in the GLP-1RA cohort would attenuate rather than amplify the observed treatment effect, as greater adiposity confers higher basal cardiovascular risk

Overall, our results point to a physiological significance of paracrine GLP-1 but not CCK signaling in promoting glucose-stimulated insulin secretion in both mouse and human islets, suggesting that to -cell communication through GLP-1 receptor signaling is critical in the control of islet function and glucose homeostasis

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PubMed Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JH (2011)