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Discussion The ability of bacterial populations or subpopulations of persister cells to survive high concentrations of bactericidal antibiotics for extended periods, despite lacking resistance mutations, is probably a major factor contributing to treatment failure 2,22,24,46,47,48,49

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Basic pharmacokinetic parameters including absorption, distribution, metabolism, and excretion characteristics in human subjects would inform rational dosing strategies and identify potential sources of pharmacokinetic variability affecting individual response