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These are very effective at raising blood levels of B12 and preventing/reversing a deficiency
Variants predicted to significantly decrease stability, such as C23pAcF, I70pAcF, C96pAcF for PV2 and C23pAcF, I70pAcF, G119pAcF for PV3, were also included as controls
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At the same dose, a 74 kg participant had about 1.4 times the exposure of a 110 kg reference, while a 143 kg participant had about 0.8 times. Weight alone does not set the dose, but it helps explain why the trial mean transfers poorly to bodies outside the studied range
