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Despite its potent anti-diabetes effects, the clinical application of native GLP-1 is hindered by its rapid clearance by the dipeptidyl peptidase-4 (DPP-4) enzyme in vivo, resulting in a half-life of only 2 minutes [17, 18]

Accurate characterization of fatigue in patients taking GLP-1 receptor agonists requires careful clinical assessment to distinguish true fatigue from related symptoms and to identify potentially serious underlying causes

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