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Severe cases can even damage the heart and nervous systems

However, a significant portion of the mechanistic evidence, particularly for potent synergistic effects like WAT browning is derived from promising preclinical animal models, and the translation of these synergistic effects into consistent human outcomes faces several limitations

The two most common ROS that impact lipids are hydroxyl radicals (HO) and hydroperoxides (ROO) ( The GSH/GPX 4 axis prevents iron-catalyzed apoptosis, whereas cysteine (cys), an inhibitory amino acid in GSH synthesis that blocks cys input via SLC7A11, causes ferroptosis by lowering GSH levels

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Mantena, S