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The importance of these cerebrovascular functional measures are supported by the graded relationship between impairment in cerebrovascular reactivity to CO 2 (Kim et al., 2021

Others switch to a higher concentration like 5mg/mL once they reach maintenance dosing to keep unit measurements more manageable, though this requires ordering a new vial mixed at the different strength

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Contracture occurred whether rats were awake/anesthetized and persisted after sacrifice