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What the animal studies cannot tell us includes optimal human dosing, population-specific responses (elderly, children, pregnancy), long-term safety in humans, rare side effects that require large sample sizes to detect, and interactions with medications or medical conditions
In vitro , MUFA has shown the ability to induce the expression of the adiponectin gene via PPAR activation, which would result in decreased production of pro-inflammatory molecules such as IL-6 and tumour necrosis factor (TNF)-alpha (139) Polyunsaturated fatty acids, such as omega-3 fatty acids (n-3 PUFA), are mostly found in eggs, nuts, and fish, whereas omega-6 fatty acid (n-6 PUFA) is predominantly present in sunflower and other vegetable oils
Kawakami T, Inagi R, Takano H, Sato S, Ingelfinger JR, Fujita T, et al
Exenatide The first class of GLP-1s was approved
PMID: 33493036 Packer M et al (2021): Effect of Empagliflozin on Worsening Heart Failure Events in Patients With Heart Failure and Preserved Ejection Fraction: EMPEROR-Preserved Trial