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Steroid production in the skin is directly dependent on local enzymatic activity (e.g., aromatase), substrate availability, and mobilization of signal transduction and gene expression pathways, and can be modulated by several internal and external factors, including growth factors, inflammatory cytokines such as IL-1 and TNF, cAMP analogs, and glucocorticoids such as dexamethasone (Tkachenko et al., 2011

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