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Many patients may require long-term or indefinite treatment, similar to how other chronic conditions like hypertension or diabetes require ongoing medication management

If desired, the removal of the GST affinity tag is accomplished by using a site-specific protease recognition sequence located between the GST moiety and the target protein

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Laboratory studies suggest estradiol may act on serotonergic neurons to inhibit binge eating (61) and this effect is partially mediated by insulin