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Metabolic Enhancement Zepbound, a dual GIP/GLP-1 receptor agonist, plays an important role in energy balance and fat storage reduction, offering greater metabolic support compared to GLP-1-only medications

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In March 2024, the FDA added a second indication: reducing the risk of heart attack, stroke and cardiovascular death in adults with established cardiovascular disease and obesity or overweight, making it the first weight loss drug to carry that designation