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Ele atua principalmente pela modulao das vias VEGF e xido ntrico (NO)

The preclinical studies revealed hepatotoxicity in rats, the females being more susceptible than the male rats [166]

DOI: 10.1016/j.indcrop.2015.09.018 53

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References Johannessen CU, Johannessen SI: Valproate: past, present, and future

In this study, they found that miR-378 bound to IGF-1R 3UTR directly and miR-378 overexpression enhanced apoptosis of cardiomyocytes with decreased IGF-1 signaling activity suggesting that miR-378 has a role in postnatal cardiac remodeling and cardiomyocyte survival against stressors by negatively regulating IGF-1R