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Diagnosis and management of prolactin-secreting pituitary adenomas: a Pituitary Society international Consensus Statement

Upon receptor binding, IGF1R undergoes autophosphorylation, initiating downstream signaling pathways, including: Phosphoinositide 3-kinase (PI3K)/Akt pathway Mitogen-activated protein kinase (MAPK) pathway These pathways are associated with intracellular signal transduction processes, including regulation of gene expression, protein translation, and cellular signaling dynamics at the molecular level

These results emphasize the pivotal role played by the miR-221/IGF-1 pathway in regulating the proliferation of HF-KCs