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BMC Gastroenterol (2023) 23:19

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Additionally, conventional anti-obesity drugs, such as orlistat, phentermine-topiramate, and naltrexone-bupropion, can reduce body weight but have not demonstrated a clear reduction in the risk of ORCVDs

749 These findings collectively indicate that the Nrf2/GSH/GPX4 axis could be a promising therapeutic target for cerebral I/R injury